There have been quite a few comic series carrying the title of Home Sweet Home, here’s one of the more obscure ones from the late-teens. Jack Wilson, who spent a few years at NEA in Cleveland in the mid-teens, was at World Color Printing in 1919 and produced for a very short while a revival of their old Handy Andy strip. It appears that this Home Sweet Home feature was probably produced for them at the same time, though I’ve never seen these strips with syndicate stamps attached.
Home Sweet Home was a quasi-daily strip. I say quasi-daily because it was obviously sold in batches to subscribing newspapers. In every one of the (few) papers where I’ve seen it the strip runs ROP on no consistent schedule. Earliest I’ve seen is in November 1918, the latest in November 1920. However, the latest I’ve seen it running even semi-consistently is mid-1920, so that was probably shortly after the final batch went out.